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X-WR-CALNAME:Precision Microbiome Engineering Research
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X-WR-CALDESC:Events for Precision Microbiome Engineering Research
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DTSTART;TZID=America/New_York:20240201T120000
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UID:2117-1706788800-1706792400@premier-microbiome.org
SUMMARY:PreMiEr Spring 2024 Seminar Series - Dr. Nathan Crook
DESCRIPTION:Please join the NSF Engineering Research Center for Precision Microbiome Engineering (PreMiEr) for a seminar by Dr. Nathan Crook of North Carolina State University. \nAccelerated Engineering of Nonmodel Microbes \nMicrobial communities are present in a diverse range of important habitats\, including the built environment\, the human gut\, and the plant root.  In these environments\, microbial communities utilize available nutrients and produce molecules that have important impacts on their surroundings. Unfortunately\, many of the mechanisms that underlie these important behaviors remain mysterious\, which limits our ability to modify these communities when something goes wrong\, or to enhance the performance of the environment they inhabit.  Genetic modification\, such as knockout\, knock-down\, or overexpression greatly facilitates the elucidation of these mechanisms\, but this ability is absent in the majority of bacteria living in important microbial communities.   In this talk\, I will discuss the Crook Lab’s recent efforts to enable genetic engineering in nonmodel bacteria.  I will first describe a cell-free approach to “disguise” incoming foreign DNA and its application to intractable gut commensals.  Then\, I will discuss the development of a genetic toolkit for engineering the maize root microbiome.  Finally\, I will introduce our new efforts to engineer and study built-environment-derived Enterobacter ludwigii. \nOpen to the public\, but registration required for non-PreMiEr members. \nNon-PreMiEr members can register for the seminar series through this link.
URL:https://premier-microbiome.org/event/2117/
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DTSTART;TZID=America/New_York:20240215T120000
DTEND;TZID=America/New_York:20240215T130000
DTSTAMP:20260410T121757
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UID:2119-1707998400-1708002000@premier-microbiome.org
SUMMARY:PreMiEr Spring 2024 Seminar Series - Dr. Karthik Anantharaman
DESCRIPTION:Please join the NSF Engineering Research Center for Precision Microbiome Engineering (PreMiEr) and host institution The University of North Carolina at Charlotte for a talk from Dr. Karthik Anantharaman of the University of Wisconsin – Madison. \n(Re)defining the roles of phage in microbiomes \nViruses that infect microbes (typically referred to as bacteriophages\, or phages) are amongst the most abundant biological entities in all ecosystems. By infecting and lysing microbial populations\, phages can affect community composition and function which can directly impact ecosystems\, biogeochemistry\, and human health and disease. Increasing use of sequencing approaches such as metagenomics has allowed the generation of massive quantities of ‘viral dark matter’ from microbiomes\, which refers to viruses\, viral genomes\, and proteins which are poorly characterized. In this talk\, I will present novel techniques developed in our laboratory including the use of machine and deep learning approaches to study phage ecology in microbiomes. Our approaches allow for the study of phage at multiple resolutions and enable prediction of phage-microbe metabolic interactions at the scale of entire communities in human and environmental systems. Overall\, these approaches have diverse applications ranging from engineering viruses\, microbiomes\, and ecosystems\, to phage therapy. \nOpen to the public\, but registration required for non-PreMiEr members. \nNon-PreMiEr members can register for the seminar series through this link.
URL:https://premier-microbiome.org/event/2119/
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DTSTART;TZID=America/New_York:20240219T150000
DTEND;TZID=America/New_York:20240219T160000
DTSTAMP:20260410T121757
CREATED:20241202T141121Z
LAST-MODIFIED:20241202T141121Z
UID:3003-1708354800-1708358400@premier-microbiome.org
SUMMARY:PreMiEr Scholars Leadership Council (SLC) Monthly Meeting
DESCRIPTION:All PreMiEr-associated scholars (undergraduates\, graduate students\, post-docs\, and research staff) are invited to attend the monthly meetings of the Scholars Leadership Council (SLC)\, an organization led by and for the scholars that comprise the ERC.  Please check your emails from SLC Chair Jorden Rabasco for the Zoom link. \nPreMiEr-supported scholars are expected to be active members of the SLC.
URL:https://premier-microbiome.org/event/3003/
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DTSTART;TZID=America/New_York:20240229T120000
DTEND;TZID=America/New_York:20240229T130000
DTSTAMP:20260410T121757
CREATED:20231128T094108Z
LAST-MODIFIED:20231128T094108Z
UID:2121-1709208000-1709211600@premier-microbiome.org
SUMMARY:PreMiEr Spring 2024 Seminar Series - Dr. Yun Shen
DESCRIPTION:Please join the NSF Engineering Research Center for Precision Microbiome Engineering (PreMiEr) and host institution Duke University for a talk from Dr. Yun Shen of George Washington University. \nEnvironmental behaviors of pathogens in complex environments and challenges to engineering interventions \nUnderstanding the transmission of bacterial and viral pathogens in engineered water systems is of great importance to protect public health. In our study\, we investigated the fate of several key pathogens in drinking water and wastewater environments. Specifically\, we have 1) elucidated the physiological and transcriptional responses of Legionella pneumophila\, a ubiquitous opportunistic pathogen in drinking water\, to different reactive oxygen species (ROS) widely adapted in water treatment. We found that L. pneumophila exhibited resistance to ROS\, and different ROS targeted on different cell components of L. pneumophila. 2) We examined the abundance and diversity of viral vesicles from wastewater. Viral vesicles are persistent clusters of viruses cloaked in vesicles released from humans and animals\, and they are the dominant forms of some human viruses. We found several human viruses\, including norovirus\, rotavirus\, astrovirus\, and Sapporo virus\, were associated with viral vesicles in wastewater. 3) We further investigated the persistence of viral vesicles in simulated soil environment that receives treated wastewater. Remarkably\, our study demonstrated that viral vesicles exhibit greater persistence compared to free viruses in soil\, underscoring the significance of detecting and controlling these vesicles in wastewater and agricultural systems. The outcomes of our study will provide insights on optimization of wastewater treatment strategies and mitigation of health risks caused by environmental pathogens. \nOpen to the public\, but registration required for non-PreMiEr members. \nNon-PreMiEr members can register for the seminar series through this link.
URL:https://premier-microbiome.org/event/2121/
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